N-BENZYL-ISONIPECOTIC ACID

N-BENZYL-ISONIPECOTIC ACID - Names and Identifiers

Name	1-Benzylpiperidine-4-Carboxylic acid
Synonyms	N-Benzyl-Isonipecotic acid 1-BENZYL-ISONIPECOTIC ACID 1-Benzyl-Isonipecotic acid N-BENZYL-ISONIPECOTIC ACID 1-benzylpiperidin-4-carboxylic acid N-Benzylpiperidine-4-carboxylic acid 1-BENZYLPIPERIDINE-4-CARBOXYLIC ACID 1-Benzylpiperidine-4-Carboxylic acid 1-BENZYL-4-PIPERIDINE CARBOXYLIC ACID 1-Benzyl-4-piperidine Carboxylic acid 1-(phenylmethyl)-4-Piperidinecarboxylic acid
CAS	10315-07-8
InChI	InChI=1/C13H17NO2/c15-13(16)12-6-8-14(9-7-12)10-11-4-2-1-3-5-11/h1-5,12H,6-10H2,(H,15,16)

N-BENZYL-ISONIPECOTIC ACID - Physico-chemical Properties

Molecular Formula	C13H17NO2
Molar Mass	219.28
Density	1.165
Melting Point	169.0-170.5 °C
Boling Point	358.6±35.0 °C(Predicted)
Flash Point	170.7°C
Vapor Presure	9.13E-06mmHg at 25°C
Appearance	powder to crystal
Color	White to Almost white
pKa	4.02±0.20(Predicted)
Storage Condition	2-8°C
Refractive Index	1.572

N-BENZYL-ISONIPECOTIC ACID - Risk and Safety

Risk Codes	22 - Harmful if swallowed
Hazard Note	Irritant

N-BENZYL-ISONIPECOTIC ACID - Introduction

1-Benzylpiperidine-4-carboxylic acid is an organic compound with the formula C16H14N2O2.

Nature:
1-Benzylpiperidine-4-carboxylic acid is a white crystalline solid. It is acidic and can react with alkali to form the corresponding salt. It has low solubility in water and high solubility in organic solvents.

Use:
1-Benzylpiperidine-4-carboxylic acid is commonly used in drug synthesis. It can be used as a pharmaceutical intermediate for the synthesis of biologically active compounds. It is often used in the field of medicine to synthesize anti-tumor drugs, anti-cancer drugs, anti-inflammatory drugs, etc.

Preparation Method:
The preparation of 1-benzylpiperidine-4-carboxylic acid can be obtained by reacting piperidine with benzyl chloroformic acid. The reaction is generally carried out in an organic solvent such as diethyl ether, dimethylformamide and the like. The reaction conditions are generally at room temperature and the reaction time is short. The preparation process needs to pay attention to safe operation and reasonably equipped with protective facilities.

Safety Information:
1-Benzylpiperidine-4-carboxylic acid may be irritating to the skin, eyes and respiratory system. During use, it is necessary to avoid contact with skin and eyes, pay attention to personal protection, and wear appropriate protective clothing and gloves. In case of accidental inhalation or ingestion, seek medical attention immediately. During storage, it should be kept away from fire and oxidant and stored in a cool and well-ventilated place.

Last Update：2024-04-09 19:05:44